Wednesday, November 7, 2007

type of pneumocyte

Features

Type 1 pneumocyte

(squamous alveolar cell )

Type 2 pnemocyte

(great alveolar cell, secrerory epithelial cell)

Numbers

97% of alveolar surface

3% of alveolar surface

Shape

Flat simple squamous epithelial cell

Low cuboidal cell

Cytoplasm

*little

*few organelles

-cluster around nucleus

-small pnocytic vesicles

*large amount

*many organells

-large amount of mithocondria, ribosomes,ER, well develop golgi body (characteristic of secrerory cell)

Nucleus

Flat

Round

Cell division

*they are differentiated cells.

*can’t divide

*can divide.

*stem cell of both type.

Function

-small pnocytic vesicles

>assist in turnover of pulmonary surfactant.

>removal of small particles from

*secrete pulmonary surfactant

-contain phospholipid, proeins and GAG

-forms a film over the alveolar epithelium,

> which reduce surface tension

> prevents collapse of the alveolus during expiration.

Cell connection

Tight junction( among each other)

-prevent leakage of tissue fluid into the alveolar cavity.

Tight junction

-with type 1

Others

Provide very thin membrane

-gaseous exchange occur

*have membrane limited multilamellar bodies( cytosome )

-exhibit many parallel membranes (lamellae)

*theor free surface

-bulge into the alveolar cavity

-covered with short microvilli

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